Alka-Seltzer Plus Cold medicine Day and Night Effervescent Tablets dissolve quickly in hydrating water and are instantly ready to start working whether you need it during the day or at night. Each dose is individually wrapped and transforms in just 4oz of water into a liquid-fast medicine. After you drink the refreshing, sparkling solution, Alka-Seltzer Plus works quickly to relieve your worst cold symptoms. In one convenient package you get daytime relief from: Nasal & Sinus Congestion, Cough, Sore Throat, Fever, Headache and Body Aches & Pains and nighttime relief from: Cough, Sneezing, Runny Nose, Sore Throat, Nasal Congestion, Sinus Congestion & Pressure, Fever, Headache and Body Aches & Pains