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With the rise in the incidence of cardiovascular events such as strokes and heart attacks, causative factors have been more widely investigated. Many lifestyle factors can contribute to cardiovascular health, particularly diet. Consumption of highly processed, high-fat, low-fiber, sugary foods has been linked to increased total cholesterol levels, triglyceride levels, and blood sugar. These three levels have been directly linked as risk factors for the development of diseases such as diabetes, atherosclerosis, metabolic syndrome, and heart disease.

As such these are often the targets for treatment as well as prophylaxis. While cholesterol is necessary for several physiologic processes in the body, excessive amounts can be detrimental by causing atherosclerosis. Individuals with high cholesterol can reduce overall cholesterol through diet and lifestyle changes as well as supplements that reduce the production or increase excretion of cholesterol. Further the ratio of HDL: to LDL is important when discussing cholesterol-related risk.

Cholesterol found within the low-density lipoprotein (LDL-c) along with excess triglycerides can cause the formation of plaques in blood vessels. This can then lead to the narrowing of arteries and oxygen deprivation in certain tissues. However, high-density lipoproteins scavenge the blood and tissues for free cholesterol and take it back to the liver for excretion. Glucose dysregulation can shift the ratio towards LDL, and can also increase vascular damage. Traditional treatments aim to stop the production of cholesterol in the liver by inhibiting the key enzyme HMG-CoA reductase. However this approach does not increase HDL to remove the excess cholesterol already present, and it does not address glucose dysregulation, further, there are many downstream products also inhibited which can cause significant side effects. Therefore a multi-targeted approach would be most beneficial.

Bergamot (Citrus Bergamia) found in Cholesterol Control is a citrus fruit found in the coastal Calabrian region of Italy. Bergamot contains diverse and highly concentrated flavonoid profile, making it very beneficial for a number of cardiovascular processes. Further, its antioxidant properties can prevent inflammation associated with vascular damage, making this supplement effective in managing the risks associated with cardiovascular concerns.

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