Ingredients (INCI name): DICALCIUM PHOSPHATE, AQUA, GLYCERIN, SILICA, HYDROXYAPATITE (NANO), PEG-8, SODIUM LAURYL SULFATE, CELLULOSE GUM, AROMA, TRIMAGNESIUM PHOSPHATE, SODIUM METAPHOSPHATE, SODIUM CITRATE, HYDROLYZED CONCHIOLIN PROTEIN, SODIUM SACCHARIN, GLYCYRRHETINIC ACID, CETYLPYRIDINIUM CHLORIDE, LAURYL DIETHYLENEDIAMINOGLYCINE HCLFor optimal effect from nano-mHAP toothpaste, place a small amount (1–1.5 cm 0.4–0.6 inch) on your toothbrush. Brush gently but thoroughly for 3–5 minutes, ideally after each meal (three times daily recommended). After brushing, rinse lightly and spit out so that the nano-mHAP residue remaining in your saliva can continue working. Contains SANGI's Original nano-Hydroxyapatite – the Building Block of Tooth Enamel. This ingredient, first synthesized by SANGI Co., Ltd. in 1978, supports enamel remineralization and maintains tooth surface smoothness. APAGARD SERENA – Special Formula for Stain Care Smooth Enamel Finish. Formulated to help address everyday stains from coffee, tea, and wine, SERENA gently polishes the tooth surface while supporting natural remineralization. It leaves your teeth smooth, radiant, and refreshed with a delicate floral mint flavor. Cleans Teeth Helps Remove Surface Plaque. With consistent brushing, APAGARD nano-Hydroxyapatite toothpaste helps remove plaque and everyday stains, giving you a naturally brighter smile. Japan's Leading Hydroxyapatite Toothpaste is now in the US. APAGARD features Sangi's original nano-Hydroxyapatite (nano-mHAP), delivering Japan's ground-breaking oral care expertise to your daily routine.