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Doctor's Best Beauty Ceramides with Ceramide-PCD 60 Veggie Softgels

 
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Doctor's Best Beauty Ceramides with Ceramide-PCD 60 Veggie Softgels





Regular Price: US$60.00

Special Price US$49.99

Availability: In stock

Supplier: Doctor's Best

 
Be Safe - We Directly Ship From Country of Origin
 
BE SAFE
WE ONLY SHIP
FROM OFFICIAL SUPPLIERS
 
From United States
To International
In 5-10 Days
US$19.99 Shipping Fees for any Order
 

GRAND SELECTION

Think of it and most probably we have it among our grand selection of products!

 

AMAZING PRICES

Get ready for the amazing and best Supps prices ever!

 

FIXED RATE DELIVERY

Get your order anywhere on this planet within 5-10 days with a fixed rate of $19.99 (no matter the size of your order)

 

 

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A diet lacking certain nutrients may also result in reduced skin ceramide levels but can be increased through supplementation. Doctor’s Best Beauty Ceramides contain CeraLOK, 100% rice phytoceramides and natural astaxanthin that help support healthy skin from within.* This potent combination helps improve skin moisture, smoothness and reduces skin roughness.*

CeraLOK has been shown to reduce skin dryness and scaling. Astaxanthin is a potent antioxidant that helps minimize collagen degradation from UV sun exposure, protecting skin from the inside out.*

CLINICALSTUDIES

In one study researchers assessed the quantity of skin ceramidesin atopic dermatitis. Stratum corneum tissue was removed from human forearm skin with cyanoacrylate resin and placed in hexane/ethanol extraction to yield stratum corneum lipids. Ceramides were quantified by thin-layer chromatography and calculated as microgram/mg stratumcorneum. In the forearm skin of healthy individuals (n = 65), total ceramide content significantly declined with increasing age. In atopic dermatitis (n = 32-35), there was a marked ceramide reduction in lesional forearm skin compared to healthy individuals of the same age. Interestingly, non-lesional skin also exhibited a similar and significant decrease of ceramides. Among six ceramide fractions, ceramide was significantly reduced in both lesional and non-lesional skin. The researchers concluded that their findings suggest that insufficiency of ceramides in the stratum corneum is an etiologic factor in atopic dry skin.1

A similar study analyzed the relationship between epidermal lipids and barrier impairment in patients with atopic dermatitis. The quantity of ceramides in 47 patients with atopic dermatitis and 20 age- and sex-matched, healthy subjects was assessed by cyanoacrylate stripping and thin layer chromatography. In patients with atopic dermatitis, ceramide 1 and 3 levels were significantly lower compared to healthy subjects. By contrast, patients with no active signs of atopic dermatitis had a normal barrier function and intermediate values of ceramides compared to patients with atopic dermatitis with active lesions and normal subjects. The quantity of ceramide 3 was significantly correlated with transepidermal water loss impairment. This indicates that a ceramide decrease in the stratum corneum is involved with barrier impairment in atopic dermatitis. The study concluded that their findings confirm those of other authors and support the view that impaired metabolism of ceramides may cause dry skin and impaired barrier function in atopic dermatitis.2

A separate placebo-controlled, double-blind oral supplementation study of rice ceramides included 33 subjects with rough, dry skin. After six weeks of supplementation with rice ceramides at 40 mg/day subjects were analyzed for results. Dermatological analysis revealed that oral supplementation with rice ceramides significantly reduced dryness and itchiness. Water measurement showed that rice ceramides significantly increased skin moisture content. Microscopic, three-dimensional analysis of the skin revealed that rice ceramide supplementation improves skin smoothness, exfoliation and texture. The researchers concluded that long-term ingestion of rice ceramides is effective for skin moisture retention and smoothness and is, thus, an effective skin-beautifying supplement.3This study was repeated and the results were confirmed in a separate clinical trial in 2012.4

Relative levels of ceramide 1 linoleate were also depleted in winter and in aged skin, whereas ceramide 1 oleate levels increased. The researchers concluded that decreased mass levels of intercellular lipids and altered ratios of fatty acids esterified to ceramide 1 likely contribute to increased susceptibility of aged skin, perturbation of barrier function and xerosis, particularly during winter months.5

Another study analyzed levels and composition of ceramides, cholesterol, fatty acids and stratum corneum lipids collected from tape strippings at three body sites (face, hand and leg) of different age female Caucasians. Also, the influence of seasonal variation on lipid composition of stratum corneum from the same body sites was studied. The main lipid species were quantified using high-performance, thin-layer chromatography and individual fatty acids were quantified using gas chromatography. The researchers found significantly decreased levels of all major lipid species, in particular ceramides, with increasing age. Similarly, stratum corneum lipid levels of all body sites examined were dramatically depleted in winter compared with spring and summer.

This decreased level of sphingosine was relevant to the increased numbers of bacteria, including S. aureus, present in the upper str
tum corneumfrom the same subjects. This suggests that the increased colonization of bacteria found in patients with atopic dermatitis may result from a deficiency of sphingosine as a natural antimicrobial agent. The researchers concluded that vulnerability to bacterial colonizationin the skin of patients with atopic dermatitis is associated with reduced levels of a natural antimicrobial agent, sphingosine, which results from decreased levels of ceramides as a substrate and from diminished activities of its metabolic enzyme, acid ceramidase.6

FDA DISCLAIMER *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

SCIENTIFIC REFERENCES:

1. Imokawa, G et al. 1991. Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol Apr:96(4):523-6.

2. Di Nardo A et al. 1998. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol. Jan;78(1):27-30.

3. Oryza Oil and Fat Chemical Co., Ltd. 2000. Clinical Investigation of Skin-Beautifying Effect Of A Beauty Supplement Containing Rice-Derived Ceramide. June: 1-22.

4. Kim, Tae-Su et al. 2012. Improvement of Skin Moisture Capacity through Dietary Beauty Supplement Containing Ceramides Derived from Rice. Korean J Food Sci Technol. Vol. 44, No 4, p 434-440.

5. Rogers, J. et al. 1996. Stratum corneum lipids: the effect of ageing and the seasons. Arch Dermatol Res. Nov;288(12):765-70.

6. Arikawa, J et al. 2002. Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus. J Invest Dermatol. Aug;119(2);433-9.

  • Science-Based Nutrition™
  • AstaReal® The Natural Astaxanthin of Choice
  • Helps Support Healthy Skin
  • Dietary Supplement
  • Vegetarian
  • Non-GMO/Gluten Free/Soy Free

Doctor's Best Beauty Ceramides contains Ceramide-PCD®, rice phytoceramides and AstaReal® natural astaxanthin from extracts of microalgae Haematococcus pluvialis. Ceramide-PCD® has been clinically shown to support skin moisture, smoothness and elasticity, while the antioxidant properties of astaxanthin quenches free radicals and helps tackle age-related oxidative stress. This potent combination helps support healthy skin from within.

  • Helps support skin moisture, smoothness and elasticity
  • Helps quench free radicals and tackle age-related oxidative stress
  • Helps support immune response, heart and joint health
  • Veggie softgels, made with a gelatin-free alternative


Suggested Use

Adult Use: Take 1 softgel daily with food or as recommended by a nutritionally-informed physician.



Other Ingredients

Vegetarian softgel [modified food starch, glycerin, carrageenan, purified water, annatto (color)], sunflower oil, cyclodextrin, yellow beeswax, sunflower lecithin.



Warnings

This product contains natural ingredients that may vary in color.  Store in a cool dry place.



Supplement Facts
Serving Size: 1 Veggie Softgel
Serving Per Container: 60 Servings
 Amount Per Serving%Daily Value
Ceramide-PCD® (Rice Extract)40 mg
Astaxanthin (AstaReal®) (extract from Haematococcus pluvialis microalgae)6 mg
† Daily Value not established.
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