Why take SAMe?

• SAMe is a biological compound found in every living cell of the human body.*
• SAMe is limited to 3 critical metabolic pathways: trans-methylation, trans-sulfuration and amino-propylations pathways.
• If your body is not producing enough SAMe, you might feel blue or have trouble sleeping.

How does it work?

• S-Adenosyl Methionine (SAM-e) is produced by the body from ATP and the amino acid methionine which is one of the most important methyl donors in the central nervous system.
• Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems.
• SAM-e is involved in numerous biochemical reactions in tissue including the liver, joints and brain.

• Science-Based Nutrition
• Helps Supports Mood and Neural Function
• Helps Supports Joint Comfort and Mobility
• Helps Supports Liver Health and Detoxification
• Vegetarian
• Dietary Supplement
• Non-GMO
• Gluten Free
• Soy Free

Doctor's Best SAM-e helps replenish your SAM-e levels and promote a healthy mood. SAM-e (S-Adenosyl-L-Methionine) is naturally produced by your body and helps maintain healthy emotions. Various factors such as diet and aging can cause low levels of SAM-e, leaving you feeling unbalanced and moody.

Supplementing with SAM-e

Soloesse® Italian SAM-e is processed to yield the highest available percentage of the active pure S,S form which helps mediate biochemical activity in the human body.

SAM-e and Mood and Cognitive Function

SAM-e helps facilitate DNA enzymatic actions. These enzymatic actions are required for the healthy conversion of neurotransmitters responsible for healthy emotions, such a serotonin and dopamine. SAM-e also facilitates glutathione usage which improves the body's antioxidant defense and helps maintain acetylcholine levels necessary for cognitive function.

SAM-e and Joint Function

In clinical trials, SAM-e has been shown to help increase joint comfort and mobility by promoting the synthesis of proteoglycans, essential components of connective tissue.

SAM-e and Liver Function

SAM-e helps support healthy levels of glutathione, a critical antioxidant which helps protect against free radicals. SAM-e acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.

Doctor's Best utilizes only the highest quality Italian Soloesse SAM-e providing slow and targeted release for improved GI tolerance and absorption. Our Double-Strength SAM-e 400 contains 400 mg of active Soloesse SAM-e in each tablet. This ensures that you receive the most potent SAM-e product with the highest percentage of the active S,S form per serving.