Dr.cure Hair Collagen Shampoo is a powerful formula that prevents hair loss with its patented active ingredient OPC's and ensures root formation in shedding areas.
What is OPC's?
In 1534, Jacques Cartier, a French explorer, organized an expedition to the St. Lawrence River in New York during the winter. After a while, the fruits and vegetables in their food depots ran out, and the group tried to survive with salted meat and biscuits in the cold winter conditions. Over time, the crew began to show signs of scurvy, and no one had any idea what the condition was. At the suggestion of an old Indian, they managed to survive by making tea from the bark and needles of pine trees and drinking it.
Professor Jacques Masquelier of the University of Bordeaux, France, was intrigued by the story when he read Cartier's book and assumed that pine bark must contain flavonoids with ascorbate-like effects, as well as vitamin C. Thus, a comprehensive study was initiated on pine bark-derived OPCs, which Masquelier called pycnogenols. OPCs are now known as Oligomeric ProanthoCyanidins complexes (OPC's) or Procyanidolic Oligomers (PCO's).
In 2014, Professor Yasar Demir began working on how OPCs affect hair follicle cells. In this study, it was concluded that OPCs remove excess oxygen from cells and regulate blood circulation in capillaries, repair and improve collagen tissue, and normalize hair root cells, stimulate passive hair root cells and support hair formation.
In 2020, Mugla, Annox Kozmetik Ltd. Sti. examined the pine species in Mugla province and districts and started producing OPC's from an endemic pine species growing in a special region in this area. The company, which continues its studies on OPC's, has patented the pine species it uses and the oligomeric proanthocyanidin complexes it produces and offered its special shampoos and hair serums for sale under the brand name "Dr. Cure". Prof. Dr. Yasar Demir has been an Academic Consultant for Dr.cure Organic since July 2020.
OPC's Molecular Structure?
Proanthocyanidins are naturally occurring plant metabolites found widely in fruits, vegetables, nuts, seeds, flowers, and bark. Other plant sources of proanthocyanidins include wine, cranberries and blueberries, birch, ginkgo, and hawthorn leaves. Also known as procyanidins, these substances are the primary precursors of blue-violet and red pigments in plants. These compounds are part of a specific group of polyphenolic compounds (flavonoids).
Flavonoids are further categorized into subgroups. Proanthocyanidins belong to the category known as condensed tannins, one of the two main categories of plant tannins. Tannins are highly hydroxylated structures that can form insoluble complexes with carbohydrates and protein, a measure of their astringency, based on their ability to cause precipitation of salivary proteins. Polyphenolics, including proanthocyanidins, constitute a significant portion of the tannins found in wine and contribute greatly to the color and flavor of red wines in particular.
Proanthocyanidins are high molecular weight polymers containing the monomeric units flavan-3-ol (( ) catechin and (-) epicatechin). Oxidative condensation occurs between the C-6 or C-8 carbons of rings A and B, linked by the heterocycle carbon C-4. Procyanidins B1-B4, characterized by a C4-C8 linkage, are the most common dimers, sometimes together with the corresponding C4-C6 linked isomers (B5-B8). At a symposium titled "Free Radicals in Biotechnology and Medicine" held in London in 1990, it was reported that esterification of (-)-epicatechin and procyanidin B2 with gallic acid increased their free radical scavenging ability.
Information has also been provided indicating that dimeric proanthocyanidins with a C4-C8 linkage have greater free radical scavenging activity than those with a C4-C6 linkage and that these gallate esters are only found in grape seed extract. Grape seed extract contains OPCs consisting of dimers or trimers of ( )-catechin and (-)-epicatechin.
4-6 Procyanidin dimers consist of procyanidins B1, B2, B3, B4, B5, B6, B7, and B8. There are six procyanidin trimers containing procyanidins C1 and C2. In addition, several gallolyl procyanidins, the most common of which are gallate esters of dimeric procyanidins, and some free gallic acid are present.
Tetramers or more of these flavonols are known as polymeric proanthocyanidins, and the shrinkage of the molecule increases accordingly. Oligomeric proanthocyanidins are therefore less astringent, less strongly bound to proteins, and more soluble and mobile in the body.
What Are OPC's Biological Properties?
The biological properties of flavonoids, including proanthocyanidins, have been extensively reviewed. Proanthocyanidins have also been shown to prevent lipid peroxidation, platelet aggregation, capillary permeability and fragility, and to affect enzyme systems such as phospholipase A2, cyclooxygenase, and lipoxygenase. The free radical scavenging abilities of proanthocyanidins are well documented and have received the most attention.
In vivo studies have shown that grape seed proanthocyanidin extract is a better free radical scavenger and inhibitor of oxidative tissue damage than vitamin C, vitamin E succinate, vitamin C and vitamin E succinate, and beta carotene. In addition, in vitro experimental results have shown that proanthocyanidins have the property of competitively inhibiting the activity of xanthine oxidase, an important generator of free radicals, elastase, collagenase, hyaluronidase, and beta-glucuronidase, as well as specificity for the hydroxyl radical.
OPCs also showed preferential binding to regions characterized by high glycosaminoglycan content (epidermis, capillary wall, gastrointestinal mucosa, etc.). This property makes them useful for reducing vascular permeability and increasing capillary strength, vascular function, and peripheral circulation.
What is Genetic Hair Loss?
Adrogenic Alopecia is triggered by testosterone, which begins to be secreted intensively in the body. Testosterone (male hormone) interacts with some enzymes in the hair follicles and turns into the Dihydrotestosterone hormone, known as DHT. This is the hormone that causes hair to weaken and fall out.
In people with high DHT sensitivity, hair root cells go into sleep mode. In this case, hair follicles weaken, causing existing hair to thin and not grow, while not being able to form new hair. Vascular development decreases around the hair cells in the sleep phase, in other words, blood circulation in the capillaries that feed the hair root decreases. Baldness occurs due to this vicious cycle.
How is Genetic Hair Loss Treated?
If you are facing this type of hair loss, you have two solutions.
1- Suppressing the DHT hormone with hormone therapy.
We recommend that you see a specialist for hormone therapy.
2- Eliminating the negative effects of the DHT hormone on the hair follicles.
Using the right shampoos and herbal oils formulated to reduce the negative effects of the DHT hormone on the hair follicles will also be very beneficial.
Dr.cure Collagen Shampoo and Serum It repairs damaged capillaries in hair root cells with OPC's, Collagen, Ginseng, Coenzyme-Q10, Pro-Vitamin B5 and Vitamin E and normalizes these cells. In normalized cells, healthy and passive roots leave their dormant state and your hair regains its health
