Pain relief is now more advanced than ever. Icy Hot Advanced Relief Pain Relief Patches contain 50% more medicine than the leading patch to give you powerful, long-lasting pain relief. Use these pain patches on minor aches and pains associated with back pain, muscle pain, arthritis pain, tendonitis, bursitis, sprains, bruises and cramps. The breathable fabric of Icy Hot Pain Patches make them easy to apply and allow them to comfortably stay in place for hours. Each box contains five pain patches. HOW TO USE: Fold the pain patch in half to remove the center section of the film backing. Apply the exposed adhesive portion of the patch to the site of pain. Next, remove the film backing from both sides of the patch and finish applying to skin. Use one patch for up to 12 hours use only once per day.