Çinko
Olgunlasmamis sperm dis zarin olusturulmasinda ve spermin kuyrugunda çinko gereklidir. Bu olmadan, sperm vajinanin, rahim agzinda ve döllenmenin gerçeklesmesi için rahim içine uzun bir yolculuk yapmak için hareketlilik ve güç veren bir asamaya olgunlasamaz.
chu ds. Zinc: A small molecule with a big impact on sperm function. Plos biol. 2018 jun 7 16(6):E2006204. Doi: 10.1371 journal.Pbio.2006204. Pmid: 29879100 pmcid: Pmc5991634.
irani m, amirian m, sadeghi r, lez jl, latifnejad roudsari r. The effect of folate and folate plus zinc supplementation on endocrine parameters and sperm characteristics in sub-Fertile men: A systematic review and meta-Analysis. Urol j. 2017 aug 29 14(5):4069-4078. Pmid: 28853101.
kerns k, zigo m, sutovsky p. Zinc: A necessary ion for mammalian sperm fertilization competency. Int j mol sci. 2018 dec 18 19(12):4097. Doi: 10.3390 ijms19124097. Pmid: 30567310 pmcid: Pmc6321397.
B6 vitamini (piridoksin)
Yapilan arastirmalarda b6 vitamininin gebelik döneminde görülen mide bulantisi ve kusmalar konusunda bazi kadinlari rahatlattigi ortaya çikmistir.
mcparlin c, o'donnell a, robson sc, beyer f, moloney e, bryant a, bradley j, muirhead cr, nelson-Piercy c, newbury-Birch d, norman j, shaw c, simpson e, swallow b, yates l, vale l. Treatments for hyperemesis gravidarum and nausea and vomiting in pregnancy: A systematic review. Jama. 2016 oct 4 316(13):1392-1401. Doi: 10.1001 jama.2016.14337. Pmid: 27701665.
sharifzadeh f, kashanian m, koohpayehzadeh j, rezaian f, sheikhansari n, eshraghi n. A comparison between the effects of ginger, pyridoxine (vitamin b6) and placebo for the treatment of the first trimester nausea and vomiting of pregnancy (nvp). J matern fetal neonatal med. 2018 oct 31(19):2509-2514. Doi: 10.1080 14767058.2017.1344965. Epub 2017 jul 7. Pmid: 28629250.
doxylamine pyridoxine for nausea and vomiting in pregnancy. Drug ther bull. 2019 mar 57(3):38-41. Doi: 10.1136 dtb.2018.000053. Epub 2019 jan 31. Pmid: 30705026.
Betain
Betain (trimetil glisin), hmt (betain-Homosistein metil transferaz) enziminin bozulma olasiligini ortadan kaldirir.
zhao g, he f, wu c, li p, li n, deng j, zhu g, ren w, peng y. Betaine in inflammation: Mechanistic aspects and applications. Front immunol. 2018 may 24 9:1070. Doi: 10.3389 fimmu.2018.01070. Pmid: 29881379 pmcid: Pmc5976740.
L-Sistein
L-Sistein, vücudun glutatyon üretmek için ihtiyaci vardir.
rushworth gf, megson il. Existing and potential therapeutic uses for n-Acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits. Pharmacol ther. 2014 feb 141(2):150-9. Doi: 10.1016 j.Pharmthera.2013.09.006. Epub 2013 sep 28. Pmid: 24080471.
pei y, liu h, yang y, yang y, jiao y, tay fr, chen j. Biological activities and potential oral applications of n-Acetylcysteine: Progress and prospects. Oxid med cell longev. 2018 apr 22 2018:2835787. Doi: 10.1155 2018 2835787. Pmid: 29849877 pmcid: Pmc5937417.
paul bd, sbodio ji, snyder sh. Cysteine metabolism in neuronal redox homeostasis. Trends pharmacol sci. 2018 may 39(5):513-524. Doi: 10.1016 j.Tips.2018.02.007. Epub 2018 mar 9. Pmid: 29530337 pmcid: Pmc5912966.
Coenzim q10
Kadin dogurganligi yasinin azalmasi genellikle mitokondriyal aktivitede azalma ile iliskilidir. Mitokondri, enerji üretiminin büyük bir kismindan sorumlu olan hücrenin bir bilesenidir. Koenzim q10 enerji üretimi için gereklidir.
xu y, nisenblat v, lu c, li r, qiao j, zhen x, wang s. Pretreatment with coenzyme q10 improves ovarian response and embryo quality in low-Prognosis young women with decreased ovarian reserve: A randomized controlled trial. Reprod biol endocrinol. 2018 mar 27 16(1):29. Doi: 10.1186 s12958-018-0343-0. Pmid: 29587861 pmcid: Pmc5870379.
díaz-Casado me, quiles jl, barriocanal-Casado e, gonzález-García p, battino m, lópez lc, varela-López a. The paradox of coenzyme q10in aging. Nutrients. 2019 sep 14 11(9):2221. Doi: 10.3390 nu11092221. Pmid: 31540029 pmcid: Pmc6770889.
ben-Meir a, burstein e, borrego-Alvarez a, chong j, wong e, yavorska t, naranian t, chi m, wang y, bentov y, alexis j, meriano j, sung hk, gasser dl, moley kh, hekimi s, casper rf, jurisicova a. Coenzyme q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging cell. 2015 oct 14(5):887-95. Doi: 10.1111 acel.12368. Epub 2015 jun 26. Pmid: 26111777 pmcid: Pmc4568976.
B3 vitamini (niasin)
B3 vitamini takviyesi niasin, genital bölgedeki kan akisini artirmaya yardimci olan bir vazodilatatör görevi görür.
B2 vitamini (riboflavin)
Vücut için enerji üretmenin yani sira, riboflavin antioksidan olarak çalisir ve vüculta serbest radikaller olarak bilinen zararli parçaciklarla mücadele eder.
saedisomeolia a, ashoori m. Riboflavin in human health: A review of current evidences. Adv food nutr res. 2018 83:57-81. Doi: 10.1016 bs.Afnr.2017.11.002. Epub 2018 feb 2. Pmid: 29477226.
Miyoinozitol d-Kiro-Inozitol
Açiklanamayan dogurganlik problemi olan insanlarda üreme hormon düzeylerini dengelemeye yardimci olur. Açiklanamayan infertiliteye sahip erkek hastalarda sperm sayisini ve dogurganlik hizini artirir. Düsük sperm sayisinda sperm hareketliligini ve mitokondriyal islevini yükseltir. Polikistik over sendromu (pcos) olan kadinlarda dogurganlikta yardimci olabilir. Düzgün yumurtalik fonksiyonu için gereklidir ve ositlerin (yumurtalar) ve embriyolarin genel kalitesini arttirir.
milewska em, czyzyk a, meczekalski b, genazzani ad. Inositol and human reproduction. From cellular metabolism to clinical use. Gynecol endocrinol. 2016 sep 32(9):690-695. Doi: 10.1080 09513590.2016.1188282. Epub 2016 sep 5. Pmid: 27595157.
artini pg, di berardino om, papini f, genazzani ad, simi g, ruggiero m, cela v. Endocrine and clinical effects of myo-Inositol administration in polycystic ovary syndrome. A randomized study. Gynecol endocrinol. 2013 apr 29(4):375-9. Doi: 10.3109 09513590.2012.743020. Epub 2013 jan 22. Pmid: 23336594.
condorelli ra, la vignera s, mongioì lm, vitale sg, laganà as, cimino l, calogero ae. Myo-Inositol as a male fertility molecule: Speed them up! Eur rev med pharmacol sci. 2017 jun 21(2 suppl):30-35. Pmid: 28724176.
C vitamini
Adrenal bezlerde ve gonadlarda steroid hormonlarin sentezinde düzenleyici olarak rol oynar.
ji yl, wang z, wang h, zhang c, zhang y, zhao m, chen yh, meng xh, xu dx. Ascorbic acid protects against cadmium-Induced endoplasmic reticulum stress and germ cell apoptosis in testes. Reprod toxicol. 2012 nov 34(3):357-63. Doi: 10.1016 j.Reprotox.2012.04.011. Epub 2012 may 5. Pmid: 22569276.
