Wellcare Melatonin 3 mg 60 Tablets
Melatonin is an important neurohormone found in humans and many other living organisms, isolated from the pineal gland of cattle in 1958.
In humans, melatonin can be synthesized in the pineal gland, as well as in the liver, kidney, gastrointestinal system, adrenal gland, heart, genital glands, uterus, platelets, leukocytes, natural killer cells, and other immune system cells.
Eighty percent of the melatonin circulating in the human body is synthesized in the pineal gland, while the amount of melatonin synthesized in other organs is very low, so it does not contribute significantly to blood circulation.
One of the most important factors in regulating human sleep is exposure to light and darkness. Melatonin, which initiates the onset of sleep and improves sleep quality, plays an active role in regulating the biological clock and circadian rhythm (such as the sleep-wake cycle, heart rate, blood pressure, body temperature, hormone release, metabolic activities, personal performance, and mood changes), begins to be synthesized in darkness, and its synthesis comes to a halt with the arrival of light.
Melatonin synthesis begins with darkness. Melatonin begins to increase between 9:00 PM and 10:00 PM, reaching a peak between 11:00 PM and 5:00 AM, with its blood levels increasing by a factor of 3-10. Between 5:00 AM and 7:00 AM, melatonin synthesis begins to decline, falling to basal levels after 7:00 AM.
Melatonin synthesis varies with age. In children, it reaches its highest level between the ages of 3 and 5, while in youth, it increases to adult levels and remains at these levels for up to 35-40 years. However, with aging, a decrease in the pineal gland's rhythm and other factors lead to a decrease in melatonin synthesis and release.
General Benefits of Melatonin:
Melatonin, the hormone that improves the human sleep cycle and sleep quality, also has various other properties in addition to its many physiological effects. These properties include:
It is a powerful antioxidant and can scavenge free radicals.
Anti-inflammatory effect.
Immunomodulatory effect.
May delay aging.
Optimization of the gastrointestinal system.
May protect gastrointestinal tissues against oxidative stress.
Skin health.
Sexual maturation and body temperature regulation.
.
Melatonin Articles:
Vasey C, McBride J, Penta K. Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin. Nutrients 2021 Sep 30 13(10):3480. doi: 10.3390 nu13103480. PMID: 34684482 PMCID: PMC8538349.
Tordjman S, Chokron S, Delorme R, Charrier A, Bellissant E, Jaafari N, Fougerou C. Melatonin: Pharmacology, Functions and Therapeutic Benefits. Curr Neuropharmacol. 2017 Apr 15(3):434-443. doi: 10.2174 1570159X14666161228122115. PMID: 28503116 PMCID: PMC5405617.
Kvetnoy I, Ivanov D, Mironova E, Evsyukova I, Nasyrov R, Kvetnaia T, Polyakova V. Melatonin as the Cornerstone of Neuroimmunoendocrinology. Int J Mol Sci. 2022 Feb 6 23(3):1835. doi: 10.3390 ijms23031835. PMID: 35163757 PMCID: PMC8836571.
Ingredients:
Bulking Agent Microcrystalline Cellulose, Melatonin, Stabilizer Polyvinylpyrrolidone, Anti-caking Agent Magnesium Salts of Fatty Acids, Anti-caking Agent Silicon Dioxide.
Ingredient Name:
Quantity (1 tablet) Melatonin 3 mg
Warnings and Precautions:
Not for use by pregnant or breastfeeding women or persons under the age of 18.
Do not drive, operate machinery, or consume alcohol while using this product.
Should not be used for more than two months.
Not used to prevent or treat diseases.
Supplementary foods do not replace a normal diet.
Consult your doctor during pregnancy, breastfeeding, or if you are ill or taking medication.
Do not exceed the recommended daily serving.
Keep out of reach of children.
The recommended use-by date (BEST) and batch number are on the packaging.
Directions for Use
It is recommended for adults to take one tablet daily, half to one hour before bedtime.
| active ingredient | Quantity 1 tablet |
|---|
| melatonin | 3mg |
