NEW LABEL COMING SOON. The formula is the same, but because of changes in Folate labeling requirements, the label is changing to reflect the bio-availability of folate. 5-MTHF is 1.7 times more bioavailable than naturally occurring folate, so the newer label lists 1700 mcg DFE (Dietary Folate Equivalents). You might receive either label over the next few months Life-Extension Optimized Folate A Folic Acid / B9 Vitamin Supplement Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. Why Choose Life Extension's Optimized Folate 700% more bioavailable than folic acid Non-GMO Vegetarian tablets Unlike other brands that use folic acid, Life Extension's Folate is made from 5-Methyltetrahydrofolate because it is up to seven times more bioactive. By depleting excess homocysteine, LifeExtension folate benefits cardiovascular health and nervous system function. Health benefits Supports neurotransmitter synthesis Maintains healthy homocysteine levels Importance of Maintaining Healthy Homocysteine Levels People with elevated homocysteine levels have a greater risk of cognitive decline. (4) Unlike folic acid, Life Extension 5-MTHF (in this Optimized Folate supplement) is able to cross the blood-brain barrier, which is especially important for people with cognitive difficulties, to enhance the synthesis of acetylcholine in the brain the neurotransmitter associated with memory. Choose Life Extention's Optimized Folate because it is already in the bioactive state, unlike traditional folate. Add to your cart because you deserve the best folate supplement. 4. N Engl J Med. 2002 Feb 14346(7):476-83.